GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7116495 | 1 | rs7103210 | chr11:71648966 | FAM86C | chr11:71498557-71512276:+ | 0.3 | 3.83 | 0.000142 | Severe influenza A (H1N1) infection |
| THCA | cis | rs1801516 | 1 | rs7103222 | chr11:108309239 | ACAT1 | chr11:107992258-108018889:+ | -0.26 | -6.12 | 1.91E-9 | Melanoma |
| THCA | cis | rs11026091 | 1 | rs7103969 | chr11:3260150 | MRGPRE | chr11:3249042-3253616:- | -0.19 | -3.69 | 0.000253 | Multiple sclerosis |
| THCA | cis | rs11026091 | 1 | rs7104094 | chr11:3260259 | MRGPRE | chr11:3249042-3253616:- | -0.19 | -3.81 | 0.000156 | Multiple sclerosis |
| THCA | cis | rs7107174 | 1 | rs7104222 | chr11:78007169 | NARS2 | chr11:78147017-78285909:- | -0.36 | -6.72 | 5.15E-11 | Testicular germ cell tumor |
| THCA | cis | rs11026091 | 1 | rs7104488 | chr11:3259830 | MRGPRE | chr11:3249042-3253616:- | -0.18 | -3.58 | 0.000372 | Multiple sclerosis |
| THCA | cis | rs2455601 | 1 | rs7104661 | chr11:8902501 | TMEM9B | chr11:8968840-8986481:- | -0.24 | -4.43 | 1.18E-5 | Schizophrenia |
| THCA | cis | rs7104764 | 1 | rs7104764 | chr11:229977 | PSMD13 | chr11:236808-252984:+ | -0.22 | -6.78 | 3.46E-11 | Menarche (age at onset) |
| THCA | cis | rs7104764 | 1 | rs7104764 | chr11:229977 | SIRT3 | chr11:214625-236931:- | 0.12 | 3.44 | 0.000626 | Menarche (age at onset) |
| THCA | cis | rs559928 | 1 | rs7105178 | chr11:64145109 | VEGFB | chr11:64002266-64006258:+ | 0.13 | 3.59 | 0.000372 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| THCA | cis | rs7111546 | 1 | rs7105185 | chr11:22817586 | SVIP | chr11:22843600-22851382:- | 0.21 | 3.42 | 0.000672 | Dialysis-related mortality |
| THCA | cis | rs7927771 | 1 | rs7105282 | chr11:47805614 | C1QTNF4 | chr11:47611216-47615961:- | -0.3 | -5.23 | 2.56E-7 | Subjective well-being |
| THCA | cis | rs7116495 | 1 | rs7106748 | chr11:71645803 | FAM86C | chr11:71498557-71512276:+ | 0.32 | 3.89 | 0.000116 | Severe influenza A (H1N1) infection |
| THCA | cis | rs7107174 | 1 | rs7107174 | chr11:77997936 | NARS2 | chr11:78147017-78285909:- | -0.35 | -6.33 | 5.53E-10 | Testicular germ cell tumor |
| THCA | cis | rs710865 | 1 | rs710865 | chr1:19568972 | CAPZB | chr1:19665274-19811992:- | 0.12 | 3.48 | 0.000552 | Brain structure |